Cardiac Output Guide

Cardiac Output Formula

Cardiac output (CO) = Heart rate (HR) × Stroke volume (SV). Normal resting values: HR = 60-100 bpm, SV = 60-100 mL, CO = 4.0-8.0 L/min. An average resting adult pumps approximately 5 L/min — the entire blood volume circulates once per minute. Cardiac index (CI) = CO / body surface area (BSA). Normal CI = 2.5-4.0 L/min/m². CI adjusts for body size — useful for comparing across individuals. The Fick principle: CO = O₂ consumption / (arterial O₂ content − venous O₂ content) — the gold standard for

Stroke Volume and Its Determinants

Stroke volume (volume ejected per beat) is determined by three factors: preload (end-diastolic volume — the 'fill'), afterload (resistance against which the heart pumps — affected by blood pressure and peripheral resistance), and contractility (intrinsic strength of the cardiac muscle). Frank-Starling law: within limits, increased preload increases stroke volume (the more the ventricle fills, the harder it contracts). Exercise dramatically increases SV — elite athletes can reach SV of 150-200 mL

Mean Arterial Pressure

MAP = (systolic + 2 × diastolic) / 3. This approximation accounts for the fact that diastole (heart relaxation) occupies approximately two-thirds of the cardiac cycle. MAP represents the average pressure driving blood through the systemic circulation. Normal MAP = 70-100 mmHg. MAP < 60 mmHg is associated with inadequate organ perfusion (critical in trauma and septic shock). MAP is more clinically relevant than either systolic or diastolic pressure alone for assessing perfusion pressure to vital

Cardiac Output During Exercise

At rest: CO ≈ 5 L/min. Moderate exercise: CO doubles to 10-12 L/min. Maximal exercise (trained individual): CO reaches 20-25 L/min. Elite endurance athletes: CO up to 35-40 L/min during maximal exercise. Most of the increase comes from increased HR (up to 200 bpm) but SV also increases (from 70 mL at rest to 150+ mL during intense exercise). VO₂ max (maximal oxygen consumption) = CO max × maximal arteriovenous O₂ difference. Training increases CO by increasing both maximal SV (via cardiac hypert

Not medical advice. This calculator is for general information and education only. Figures are estimates and may not reflect your circumstances. For decisions, consult your GP or a qualified healthcare professional. See our editorial standards.

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